Sulforaphane Mitigates High-Fat Diet-Induced Obesity by Enhancing Mitochondrial Biogenesis in Skeletal Muscle via the HDAC8-PGC1α Axis.
Hee YangGihyun HurTae Kyung LeeJong-Eun KimJong Hun KimJong Rhan KimJiyoung KimJung Han Yoon ParkJong-Eun KimPublished in: Molecular nutrition & food research (2023)
SFN prevents obesity-related metabolic dysregulation by enhancing mitochondrial biogenesis and function via targeting the HDAC8-PGCα axis. These results suggest SFN as a beneficial anti-obesity agent providing new insight into the role of HDAC8 in the PGC1α-mediated mitochondrial biogenesis, which may be a novel and promising drug target for metabolic diseases.