Efficient Antimicrobial Effect of Alginate-Catechol/Fe 2+ Coating on Hydroxyapatite toward Oral Care Application.

Reducing the formation of oral bacterial biofilms is critical to prevent common dental diseases. Though many strategies for restricting bacterial adhesion on tooth surfaces have been reported, a simple method for efficient oral bacteriostasis is still highly expected. Herein, we have proved a soft gel made of an alginate-catechol conjugate (SA-DA) and the ferrous cation (Fe 2+ ) as an effective antibacterial coating on hydroxyapatite (HAP, a tooth model). As suggested by quartz crystal microbalance (QCM) measurements, SA-DA/Fe 2+ coating possessed a high binding affinity to HAP without destruction by either immersion in artificial saliva or simulated tooth brushing. Significantly less protein (bovine serum albumin) and Streptococcus mutans ( S. mutans , an oral bacterial model) could be found on HAP after coating with SA-DA/Fe 2+ , indicating that the prepared gel could resist well the adhesion of biofouling and microbes due to its hydrophilicity. Notably, such an antibacterial effect (around 70% S. mutans was inhibited) could be maintained for 3 d, which resulted from the extremely good stability of SA-DA/Fe 2+ coating, as confirmed by QCM analysis. Our results may offer possibilities for developing applications in order to further improve oral hygiene.