The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals.

Alicia López-de-EguiletaSara López-GarcíaCarmen LageAna PozuetaMaría García-MartínezMartha KazimierczakMaría BravoJuan IrureMarcos López-HoyosPedro Muñoz-CachoNoelia Rodríguez-PerezDiana Tordesillas-GutiérrezAlexander GoikoetxeaClaudia NebotEloy Rodríguez-RodríguezAlfonso CasadoPascual Sánchez-Juan

Published in: Alzheimer's research & therapy (2022)

We found a significant correlation between Tau (pTau) and neurodegeneration biomarkers (tTau and hippocampus volume) with GCL degeneration and, to a lesser degree, with damage in RFNL. OCT analysis constitutes a non-invasive and unexpensive biomarker that allows the detection of neurodegeneration in cognitively asymptomatic individuals.

Keyphrases

cognitive decline
mild cognitive impairment
single cell
optical coherence tomography
cerebrospinal fluid
loop mediated isothermal amplification
stem cells
label free
blood brain barrier