SARA captures disparate progression and responsiveness in spinocerebellar ataxias.

Emilien PetitTanja Schmitz-HübschGiulia CoarelliHeike JacobiAnna HeinzmannKarla P FigueroaSusan L PerlmanChristopher M GomezGeorge R WilmotJeremy D SchmahmannSarah H YingTheresa A ZesiewiczHenry L PaulsonVikram G ShakkottaiKhalaf O BusharaSheng-Han KuoMichael D GeschwindGuangbin XiaStefan M PulstS H SubramonyClaire EwenczykAlexis BriceAlexandra DurrThomas KlockgetherTetsuo AshizawaSophie Tezenas du Montcel

Published in: Journal of neurology (2024)

SARA and its item's progression pace showed high heterogeneity across cohorts and SCAs. However, no combinations of items improved the responsiveness in all SCAs or populations taken separately.

Keyphrases

single cell
genetic diversity