Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells.
Tomokazu FujimotoToshihiro InoueSaori OhiraNanako Awai-KasaokaTakanori KamedaMiyuki Inoue-MochitaHidenobu TaniharaPublished in: Journal of ophthalmology (2017)
Using microarray analysis, Y-27632 was shown to upregulate antioxidative genes including catalase and partially reduce ROS production and cell death by oxidative stress caused by menadione.
Keyphrases
- cell death
- cell cycle arrest
- induced apoptosis
- oxidative stress
- signaling pathway
- dna damage
- anti inflammatory
- protein kinase
- bioinformatics analysis
- endoplasmic reticulum stress
- genome wide
- bone mineral density
- pi k akt
- ischemia reperfusion injury
- diabetic rats
- genome wide identification
- cell proliferation
- body composition
- transcription factor
- genome wide analysis