Phenotypic variance in monozygotic twins with SCA3.

Hua ZhaoLu YangYi DongZhi-Ying Wu

Published in: Molecular genetics & genomic medicine (2020)

It is the first time to report SCA3 monozygotic twin worldwide. The role of epigenetic factors in the phenotype variance deserved more attention. The DNA methylation may influence the phenotypic variance by altering the occurrence time and severity of symptoms, indicating its potential in alleviating the disease.

Keyphrases

dna methylation
gene expression
genome wide
risk assessment
working memory
gestational age
sleep quality
depressive symptoms
physical activity
preterm birth