Individual brain metabolic connectome indicator based on Kullback-Leibler Divergence Similarity Estimation predicts progression from mild cognitive impairment to Alzheimer's dementia.

Min WangJie-Hui JiangZhuangzhi YanIan AlbertsJingjie GeHuiwei ZhangChuan-Tao ZuoJintai YuAxel RomingerKuangyu Shinull null

Published in: European journal of nuclear medicine and molecular imaging (2020)

The KLSE indicator identifies abnormal brain networks predicting an individual's risk of conversion from MCI to AD, thus potentially constituting a clinically applicable imaging biomarker.

Keyphrases

mild cognitive impairment
cognitive decline
resting state
functional connectivity
white matter
high resolution
genome wide
gene expression
dna methylation
brain injury
blood brain barrier