Treponema pallidum protein Tp47 induced prostaglandin E2 to inhibit the phagocytosis in human macrophages.

D-Y YiQ-Y XuY HeX-Q ZhengTian-Ci Yang Y Lin

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

Tp47-induced PGE2 production via the PERK/NF-κB/COX-2 pathway contributed to macrophage phagocytosis inhibition, which potentially contributes to immune evasion during the T. pallidum infection.

Keyphrases

high glucose
endothelial cells
signaling pathway
adipose tissue
drug induced
endoplasmic reticulum stress
lps induced
inflammatory response
pi k akt
amino acid
endoplasmic reticulum