An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation.
Martin BenderBruno ReichartConstanca FigueiredoJonathan M BurgmannMaria LeuschenFelicia WallJulia RadanElisabeth NeumannMaren MokelkeInes ButtgereitSebastian MichelReinhard EllgassStefanie EgererAndreas LangeAndrea BaehrBarbara KesslerElisabeth KemterNikolai KlymiukJoachim DennerAntonia W GodehardtRalf R TönjesChristian HaglMichaela GebauerUli BinderArne SkerraDavid AyaresEckhard WolfMichael SchmoeckelPaolo BrennerMatthias LänginJan-Michael AbichtPublished in: Xenotransplantation (2024)
Our preclinical experience with the anti-inflammatory drug therapy proved that controlling of inflammation and coagulation disorders in xenotransplantation is possible and well-practicable under the condition that transmission of pathogens, especially of PCMV/PRV to the recipient is prevented because PCMV/PRV also induces inflammation and coagulation disorders. Our anti-inflammatory regimen should also be applicable and effective in the clinical setting of cardiac xenotransplantation.