Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation.
Shinobu Miyazaki-AnzaiMasashi MasudaYuji ShiozakiAudrey L KeenanMichel ChoncholClaus KremoserMakoto MiyazakiPublished in: Kidney360 (2021)
This study demonstrates that DCA plays a causative role in regulating CKD-dependent vascular diseases through ER stress-mediated ATF4 activation.