Self-Assembled Perylene Diimide (PDI) Nanowire Sensitized In 2 O 3 @MgIn 2 S 4 S-Scheme Heterojunction as Photoelectrochemical Biosensing Platform for the Detection of CA15-3.

Inorganic/organic heterojunctions show promising applications as high-performance sensing platforms for photoelectrochemical (PEC) immunosensors. This work reports constructing a PEC biosensor for CA15-3 based on a self-assembled perylene diimide (PDI) nanowire sensitized In 2 O 3 @MgIn 2 S 4 S-scheme heterojunction platform. P-type semiconductor Cu 2 O nanoparticles were designed as a signal burst source and were used as immunoassay labels. The carboxyl group on self-assembled PDI nanowires eliminates the step of additional surface functionalization for covalent immobilization of the capture elements. The π-π stacking of PDI enhances electron generation efficiency, while the carboxylic acid groups on PDI promote electron transfer. The performance of the constructed sensor was validated using CA15-3 as a model. The experimental results showed that the sensor based on In 2 O 3 @MgIn 2 S 4 /PDI has excellent selectivity, stability, and reproducibility, and can sensitively detect CA15-3 in the range of 0.001-100 U·mL -1 with the detection limit of 0.00056 U·mL -1 . The sensor has a broad application prospect. It is hoped that this research work based on the unique advantages of the organic compound PDI will inspire other researchers to design light-responsive materials and promote the development of the field of photoelectrochemical sensing.