This study offered important insights at both the cellular and molecular levels into how ER signaling affects microglial heterogeneity and function. FDAMic are associated with more advanced pathologies and severe trends of cognitive decline. Their emergence could, at least in part, explain the phenomenon of greater penetrance of the APOE4 genotype found in females. The biases of FDAMic emergence toward female sex and APOE4 status may also explain why hormone replacement therapy is more effective in APOE4 carriers. The pathologic nature of FDAMic suggests that selective modulations of these cells may help to regain brain neuroimmune homeostasis, serving as a new target for future drug development.
Keyphrases
- cognitive decline
- late onset
- mild cognitive impairment
- replacement therapy
- early onset
- induced apoptosis
- inflammatory response
- neuropathic pain
- cell cycle arrest
- neoadjuvant chemotherapy
- white matter
- single cell
- current status
- oxidative stress
- lipopolysaccharide induced
- type diabetes
- endoplasmic reticulum stress
- cell death
- high fat diet
- metabolic syndrome
- spinal cord
- radiation therapy
- locally advanced
- breast cancer cells
- weight loss
- cell proliferation
- adipose tissue
- insulin resistance
- signaling pathway