Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling.

Heajin JunYan RongCatharina YihJordan HoWendy ChengTony K L Kiang

Published in: Drugs in R&D (2020)

The linear binding model best described the population pharmacokinetics of unbound phenytoin in adult subjects and may be used to improve the prediction of free phenytoin concentrations.

Keyphrases

binding protein
dna binding
protein protein
amino acid
transcription factor
small molecule