Applying pharmacokinetic/pharmacodynamic measurements for linezolid in critically ill patients: optimizing efficacy and reducing resistance occurrence.
Rasha M El-GamlNoha M El-KhodaryRania R AbozahraAyman A El-TayarSoha M El-MasryPublished in: European journal of clinical pharmacology (2022)
In critically ill patients, continuous infusion with a loading dose (GpIII) is obviously superior to continuous infusion without a loading dose (GpII) or intermittent infusion (GpI) for infection therapy. Additionally, it might limit fluctuations in plasma concentrations, which may help overcome LZD resistance.