PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition.

Vaishnavi SambandamMitchell J FrederickLi ShenPan TongXiayu RaoShaohua PengRatnakar SinghTuhina MazumdarChenfei HuangQiuli LiCurtis R PickeringJeffery N MyersJing WangFaye M Johnson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our findings suggest that NOTCH1 MUT predicts response to PI3K/mTOR inhibitors, which may lead to the first biomarker-driven targeted therapy for HNSCC, and that targeting PDK1 sensitizes NOTCH1 WT HNSCC to PI3K/mTOR pathway inhibitors.

Keyphrases

cell proliferation
cancer therapy
climate change
high grade
induced apoptosis
oxidative stress