Male and female breast cancer: the two faces of the same genetic susceptibility coin.

Susana Nunes SilvaBruno Costa GomesSaudade AndréAna FélixAntónio Sebastião RodriguesJosé Rueff

Published in: Breast cancer research and treatment (2021)

In males, XRCC1 and TP53 variants, when in heterozygosity, seem to be related with lower susceptibility for BC, contrasting with higher susceptibility for a MUTYH variant in females. These findings may help to explain the difference in incidence of BC between the two sexes.

Keyphrases

copy number
risk factors
dna repair
dna methylation
dna damage