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Characterization, modeling, and anticancer activity of L.arginase production from marine Bacillus licheniformis OF2.

Manal S SelimMarwa M MounierSayeda A AbdelhamidAhmed Abdelghani HamedMostafa M Abo ElsoudSahar S Mohamed
Published in: BMC biotechnology (2024)
L-arginase demonstrated more strong anti-cancer cells with an IC50 of 21.4 ug/ml in a dose-dependent manner. L-arginase underwent another investigation for its impact on the caspase 7 and BCL2 family of proteins (BCL2, Bax, and Bax/Bcl2). Through cell arrest in the G1/S phase, L-arginase signals the apoptotic cascade, which is supported by a flow cytometry analysis of cell cycle phases.
Keyphrases
  • cell cycle
  • flow cytometry
  • nitric oxide synthase
  • cell death
  • cell proliferation
  • induced apoptosis
  • nitric oxide
  • cell therapy
  • single cell
  • stem cells
  • mesenchymal stem cells
  • bone marrow
  • anti inflammatory