Synthesis and biological evaluation of cajaninstilbene acid and amorfrutins A-D as cytotoxic agents against human pancreatic carcinoma PANC-1 cells.

Tadafumi FujitaJianyu LinAtsushi KimishimaMasayoshi AraiHirosato Takikawa Yusuke Ogura

Published in: Bioscience, biotechnology, and biochemistry (2022)

A concise synthesis of cajaninstilbene acid was achieved in 7 steps from (E)-3,5-dimethoxystilbene in 8.6% overall yield via the Claisen rearrangement of an aryl reverse-prenyl ether as the key step. Cytotoxic activities against human pancreatic carcinoma PANC-1 cells of cajaninstilbene acid and amorfrutins A-D were also evaluated.

Keyphrases

induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
oxidative stress
signaling pathway
ionic liquid