Gukang Capsule Promotes Fracture Healing by Activating BMP/SMAD and Wnt/β-Catenin Signaling Pathways.

Xue MaJian YangTing LiuJing LiYanyu LanYonglin WangAimin WangYe Tian Yongjun Li

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

GKC promotes fracture healing by activating the Wnt/β-catenin and BMP/Smad signaling pathways and increasing osteoprotegerin (OPG) secretion by osteoblasts (OBs), which prevents receptor activator of nuclear factor kappa B ligand (RANKL) binding to RANK.

Keyphrases

nuclear factor
signaling pathway
epithelial mesenchymal transition
toll like receptor
transforming growth factor
cell proliferation
pi k akt
mesenchymal stem cells
induced apoptosis
stem cells
hip fracture
bone regeneration
immune response
mouse model