Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models.
Seok Jae LeeSoohyun KimDong Hyun JoChang Sik ChoSu Ree KimDongmin KangJisu ChaeDuck Kyun YooSuji HaJunho ChungJeong Hun KimPublished in: Communications medicine (2021)
Our results suggest that removing PDGFRβ-expressing pericytes by an ADC targeting PDGFRβ could be a potential therapeutic strategy for pathologic ocular neovascularization.
Keyphrases
- neoadjuvant chemotherapy
- vascular endothelial growth factor
- diabetic retinopathy
- mouse model
- cancer therapy
- locally advanced
- optic nerve
- diffusion weighted imaging
- lymph node
- squamous cell carcinoma
- magnetic resonance imaging
- diffusion weighted
- rectal cancer
- radiation therapy
- computed tomography
- drug delivery
- atrial fibrillation
- contrast enhanced