Intestinal injury in paracetamol overdose (ATOM-8).

Varan PerananthanFathima ShihanaAngela ChiewJacob GeorgeAndrew DawsonNicholas A Buckley

Published in: Journal of gastroenterology and hepatology (2023)

Paracetamol overdose causes concentration-related intestinal toxicity, and this is a possible explanation for the early hyperlactatemia syndrome. Intestinal toxicity has potential impacts on pharmacokinetics of other agents ingested and on the evolution of hepatotoxicity. Further studies are required to explore the mechanisms and prognostic implications of intestinal toxicity.

Keyphrases

oxidative stress
molecular dynamics
risk assessment
oxide nanoparticles
climate change
human health
anti inflammatory drugs