The presence of two reduced function variants in CYP2C9 influences the acute response to glipizide.

L ChenJosephine H LiV KaurA MuhammadM FernandezM S HudsonA B GoldfineJ C Florez

Published in: Diabetic medicine : a journal of the British Diabetic Association (2019)

Carriers of two reduced function alleles in CYP2C9 may experience an increased insulin response to glipizide and be predisposed to a higher risk of hypoglycaemia, although no effect of genotype was seen in glucose-based measurements. Further studies are needed to clarify the utility of CYP2C9 genotyping to guide sulfonylurea treatment.

Keyphrases

type diabetes
liver failure
copy number
genome wide
respiratory failure
high throughput
drug induced
glycemic control
blood glucose
intensive care unit
metabolic syndrome
dna methylation
hepatitis b virus
aortic dissection
acute respiratory distress syndrome
mechanical ventilation