Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells.

Claire GourzonesCéline BellangerSylvain LamureOuissem Karmous GadachaElvira Garcia De PacoLaure VincentGuillaume CartronBernard KleinJérôme Moreaux

Published in: Cancers (2019)

Our data demonstrate that antioxidant defenses confers resistance to high dose melphalan in MM cells, supporting that redox status in MM cells could be determinant for patients' response to melphalan.

Keyphrases

high dose
induced apoptosis
low dose
cell cycle arrest
oxidative stress
end stage renal disease
multiple myeloma
endoplasmic reticulum stress
newly diagnosed
signaling pathway
ejection fraction
chronic kidney disease
anti inflammatory
big data
peritoneal dialysis