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Small rings in the bigger picture: ring expansion of three- and four-membered rings to access larger all-carbon cyclic systems.

Bohdan BiletskyiPierre ColonnaKévin MassonJean-Luc ParrainLaurent CommeirasGaëlle Chouraqui
Published in: Chemical Society reviews (2021)
The release of the inherent ring strain of cyclobutane and cyclopropane derivatives allows a rapid build-up of molecular complexity. This review highlights the state-of-the-art of the ring expansions of three- and four-membered cycles and is organised by types of reactions with emphasis on the reaction mechanisms. Selected examples are discussed to illustrate the synthetic potential of this elegant synthetic tool.
Keyphrases
  • risk assessment