Dissecting closely linked association signals in combination with the mammalian phenotype database can identify candidate genes in dairy cattle.
Zexi CaiBernt GuldbrandtsenMogens Sandø LundGoutam SahanaPublished in: BMC genetics (2019)
Our approach can distinguish multiple QTL segregating on the same chromosome in a single analysis without manual input. Moreover, utilizing information from the mammalian phenotype database and variant effect predictor as post-GWAS analysis could benefit in candidate genes and causative mutations finding in cattle. Our study not only identified additional candidate genes for milk traits, but also can serve as a routine method for GWAS in dairy cattle.