Correlation between radiologic and pathologic extranodal extension in HPV-associated oropharyngeal cancer: Systematic review.
Tristan MoreyJohn-Charles HodgeCindy SternSuren KrishnanAndrew ForemanPublished in: Head & neck (2022)
Pretreatment determination of extranodal extension (ENE) has significant clinical implications in human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). Unfortunately there is no gold-standard imaging modality for radiological assessment of ENE in HPV+ OPSCC, leading to subjective assessments and complex decision making concerning ENE. A systematic review of diagnostic test accuracy was therefore undertaken, with five databases systemically searched to evaluate the diagnostic performance of an imaging modality for detection of ENE in HPV+ OPSCC. A meta-analysis was conducted on four CT studies using a random-effects model. While a narrative synthesis was provided for the studies using PET/CT and "CT and MRI." Out of 1772 hits, six studies were included in the review. Meta-analysis on four CT studies showed CT had an overall sensitivity of 77% and specificity of 60%. PET/CT had a sensitivity of 37.5% and specificity of 97%. "CT and MRI" had a sensitivity of 62% and specificity of 78%. Further diagnostic studies involving CT, PET/CT and MRI are ultimately required.
Keyphrases
- pet ct
- contrast enhanced
- positron emission tomography
- systematic review
- computed tomography
- dual energy
- image quality
- magnetic resonance imaging
- case control
- squamous cell carcinoma
- high grade
- magnetic resonance
- meta analyses
- decision making
- high resolution
- diffusion weighted imaging
- depressive symptoms
- neoadjuvant chemotherapy
- young adults
- squamous cell
- physical activity
- sleep quality
- tandem mass spectrometry