Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues.
Chao LiuRuiqi ZhaoLiangliang SongZhenghua LiGui-Long TianYi HeLuc Van MeerveltVsevolod A PeshkovErik V Van der EyckenPublished in: Organic & biomolecular chemistry (2021)
A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.