Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC.
Heba Mohamed ElmansiJenny Jeehan NasrAzza H RagehMohamed I El-AwadyGhada S HassanHatem A Abdel-AzizFathalla BelalPublished in: BMC chemistry (2019)
It was found that a good correlation exists between the experimental and computed log P values. In the future, these results can give a deep insight about the anti-inflammatory and analgesic activity of the newly synthesized compounds.
Keyphrases
- anti inflammatory
- ms ms
- simultaneous determination
- current status
- oxide nanoparticles
- molecular docking
- neuropathic pain
- high performance liquid chromatography
- solid phase extraction
- mass spectrometry
- diffusion weighted imaging
- tandem mass spectrometry
- computed tomography
- magnetic resonance
- spinal cord injury
- high resolution