Co-culture models of endothelial cells, macrophages, and vascular smooth muscle cells for the study of the natural history of atherosclerosis.

Martin LiuSaurabhi SamantCharu Hasini VasaRyan M PedrigiUsama M OguzSangjin RyuTimothy WeiDaniel R AndersonDevendra K AgrawalYiannis S Chatzizisis

Published in: PloS one (2023)

We present three-cell co-culture models of human atherosclerosis. These models have the potential to allow cost- and time-effective investigations of the mechanobiology of atherosclerosis and new anti-atherosclerotic drug therapies.

Keyphrases

endothelial cells
vascular smooth muscle cells
cardiovascular disease
angiotensin ii
cell therapy
high glucose
emergency department
risk assessment
mesenchymal stem cells
induced pluripotent stem cells