Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency.
Alexandra NorrickJasmina EsterlechnerElke Niebergall-RothUlf DehioSamar SadeghiHannes M SchröderSeda BallikayaNicole StemlerChristoph GanssKathrin DieterAnn-Kathrin DachtlerPatrick MerzSaadettin SelJames ChodoshClaus CursiefenNatasha Y FrankGerd U AuffarthBruce KsanderMarkus H FrankMark Andreas KluthPublished in: Stem cell research & therapy (2021)
Building upon these data in conjunction with the previously shown cornea-restoring capacity of human ABCB5+ LSCs in animal models of LSCD, we provide an advanced allogeneic LSC-based treatment strategy that shows promise for replenishment of the patient's LSC pool, recreation of a functional barrier against invading conjunctival cells and restoration of a transparent, avascular cornea.
Keyphrases
- stem cells
- induced apoptosis
- endothelial cells
- big data
- stem cell transplantation
- cell therapy
- cell cycle arrest
- bone marrow
- case report
- replacement therapy
- electronic health record
- induced pluripotent stem cells
- cell death
- machine learning
- oxidative stress
- signaling pathway
- cell proliferation
- smoking cessation
- pi k akt