Multilevel Nanoarchitecture Exhibiting Biosensing for Cancer Diagnostics by Dual-Modal Switching of Optical and Magnetic Resonance Signals.
Ruichan LvMiao FengLiyang XiaoJossana A DamascoJie TianParas N PrasadPublished in: ACS applied bio materials (2018)
In this research, the fabrication and application of a multifunctional core-shell nanoarchitecture are proposed. NaYF 4 :Yb,Er@NaYF 4 :Yb,Nd exhibits upconversion luminescence (UCL) of erbium ions but has quenched UCL emission when it is coated with MnO 2 nanosheets. This hierarchical multilevel UCNP-MnO 2 exhibits restoration of UCL and generation of a magnetic resonance imaging (MRI) signal when it is exposed to a microenvironment containing glutathione (GSH)/H 2 O 2 , which strips the MnO 2 sheets by converting them to paramagnetic Mn 2+ ions. This dual-modal switching feature of the optical emission and MRI signals provides a platform for stimuli-responsive biosensing of GSH/H 2 O 2 . Our new formulation as a dual-modal biosensor for detecting aberrant levels of intracellular GSH/H 2 O 2 associated in cancer cells could be a potential diagnostic probe to distinguish tumor cells from normal cells.
Keyphrases
- quantum dots
- magnetic resonance imaging
- energy transfer
- contrast enhanced
- magnetic resonance
- sensitive detection
- fluorescent probe
- drug delivery
- high resolution
- diffusion weighted imaging
- induced apoptosis
- cancer therapy
- computed tomography
- high speed
- living cells
- stem cells
- label free
- machine learning
- cell cycle arrest
- photodynamic therapy
- high throughput
- solid state
- squamous cell
- risk assessment
- young adults
- signaling pathway
- estrogen receptor
- climate change
- endoplasmic reticulum
- ionic liquid
- reduced graphene oxide