C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer's disease.

Angela Gomez-ArboledasMaria I FonsecaEnikö KramarShu-Hui ChuNicole D SchartzPurnika SelvanMarcelo A WoodAndrea J Tenner

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

C5aR1 ablation restores long-term potentiation in the Arctic model of AD. C5aR1 ablation rescues region specific excessive pre-synaptic loss. C5aR1 antagonist, PMX205, rescues VGlut1 loss in the Tg2576 model of AD. C1q tagging is not sufficient to induce VGlut1 microglial ingestion. Astrocytes contribute to excessive pre-synaptic loss at late stages of the disease.

Keyphrases

prefrontal cortex
mouse model
weight gain
climate change
inflammatory response
radiofrequency ablation
cognitive decline
catheter ablation
neuropathic pain
physical activity
weight loss
spinal cord injury