Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth.
Mariachiara BuccarelliQuintino Giorgio D'AlessandrisPaola MatarreseCristiana MollinariMichele SignoreAndrea CappanniniMaurizio MartiniPierluigi D'AlibertiGabriele De LucaFrancesca PediniAlessandra BoeMauro BiffoniRoberto PalliniLucia Ricci-VitianiPublished in: Journal of experimental & clinical cancer research : CR (2021)
Our results support further evaluation of therapeutics targeting oxidative stress such as elesclomol with the aim of satisfying the high unmet medical need in the management of GBM.