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Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth.

Mariachiara BuccarelliQuintino Giorgio D'AlessandrisPaola MatarreseCristiana MollinariMichele SignoreAndrea CappanniniMaurizio MartiniPierluigi D'AlibertiGabriele De LucaFrancesca PediniAlessandra BoeMauro BiffoniRoberto PalliniLucia Ricci-Vitiani
Published in: Journal of experimental & clinical cancer research : CR (2021)
Our results support further evaluation of therapeutics targeting oxidative stress such as elesclomol with the aim of satisfying the high unmet medical need in the management of GBM.
Keyphrases
  • oxidative stress
  • diabetic rats
  • reactive oxygen species
  • high glucose
  • healthcare
  • dna damage
  • induced apoptosis
  • small molecule
  • cancer therapy
  • drug induced
  • signaling pathway
  • heat shock
  • heat stress