Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth.

Mariachiara BuccarelliQuintino Giorgio D'AlessandrisPaola MatarreseCristiana MollinariMichele SignoreAndrea CappanniniMaurizio MartiniPierluigi D'AlibertiGabriele De LucaFrancesca PediniAlessandra BoeMauro BiffoniRoberto PalliniLucia Ricci-Vitiani

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our results support further evaluation of therapeutics targeting oxidative stress such as elesclomol with the aim of satisfying the high unmet medical need in the management of GBM.

Keyphrases

oxidative stress
diabetic rats
reactive oxygen species
high glucose
healthcare
dna damage
induced apoptosis
small molecule
cancer therapy
drug induced
signaling pathway
heat shock
heat stress