Overnutrition in persons with cystic fibrosis on modulator therapy and the relationship to obstructive sleep apnea.
Aesha M JobanputraKeerthana KesavarapuSreelatha NaikMaya RamagopalMatthew T ScharfSugeet JagpalPublished in: Pediatric pulmonology (2024)
Cystic fibrosis (CF) care is evolving with the ubiquitous use of modulator therapy and resultant increase in lifespan. It is important for CF clinicians to monitor the pathologic weight gain that is concomitantly being seen as obesity is a known risk factor for multiple other diseases. In this review we focus on obesity in CF, discuss screening and lifestyle considerations, outline CF-specific concerns with weight loss medications, and describe the vicious cycle of obesity and obstructive sleep apnea (OSA). We discuss screening and treatment for OSA, as it directly correlates with weight fluctuation. We offer interim recommendations for CF teams as they continue to care for this population.
Keyphrases
- cystic fibrosis
- weight loss
- weight gain
- obstructive sleep apnea
- bariatric surgery
- positive airway pressure
- pseudomonas aeruginosa
- roux en y gastric bypass
- palliative care
- body mass index
- lung function
- birth weight
- gastric bypass
- healthcare
- metabolic syndrome
- insulin resistance
- sleep apnea
- cardiovascular disease
- glycemic control
- physical activity
- neoadjuvant chemotherapy
- affordable care act
- replacement therapy
- stem cells
- health insurance
- cell therapy
- air pollution