The adjuvant effect of polymuramil, a NOD1 and NOD2 agonist, differs when immunizing mice of different inbred lines with nonstructural hepatitis C virus (Flaviviridae: Hepacivirus )proteins and is synergistically enhanced in combination with pyrogenalum, a TLR4 agonist.
Ekaterina I LesnovaOlga V MasalovaK Y PermyakovaNatalya A DemidovaVladimir T Valuev-EllistonAlexander V IvanovVladimir T Valuev-EllistonPublished in: Voprosy virusologii (2023)
Different immunogenic properties and different functions of recombinant non-structural HCV proteins indicate the feasibility of their combined inclusion in subunit vaccines. It was established for the first time that immunization with HCV proteins with a complex adjuvant (polymuramyl + pyrogenalum) has a synergistic effect, significantly exceeding the effect of each of them separately.