Efficacy of different platforms in detecting EGFR mutations using cerebrospinal fluid cell-free DNA from non-small-cell lung cancer patients with leptomeningeal metastases.
Chi-Lu ChiangHsiang-Ling HoYi-Chen YehCheng-Chia LeeHsu-Ching HuangChia-I ShenYung-Hung LuoYuh-Min ChenChao-Hua ChiuTeh-Ying ChouPublished in: Thoracic cancer (2023)
The cobas EGFR Mutation Test, ddPCR, and NGS appear to be feasible methods for analyzing CSF ctDNA in patients with NSCLC and LM. In addition, NGS may provide comprehensive information regarding the mechanisms underlying osimertinib resistance.