Single-Cell Profiling of Tumor-Associated Neutrophils in Advanced Non-Small Cell Lung Cancer.

Jinpeng ShiJiayu LiHaowei WangXuefei LiQi WangChao ZhaoLei ChengRuoshuang HanPeixin ChenHaoyue GuoZhuoran TangCaicun ZhouZhemin ZhangFengying Wu

Published in: Lung Cancer (Auckland, N.Z.) (2023)

Our study refined TAN subtypes and mapped the transcriptome landscape of TANs at single-cell resolution in advanced NSCLC, collectively indicating the heterogeneity of TANs in NSCLC. Neutrophil differentiation- and maturation-related genes were also discovered, which shed light on different functions of TAN subclones in tumor immune escape, and may further provide novel targets for immunotherapy.

Keyphrases

single cell
advanced non small cell lung cancer
rna seq
epidermal growth factor receptor
high throughput
small cell lung cancer
tyrosine kinase
dna methylation
genome wide