Ethnic Differences in Atypical Parkinsonism-is South Asian PSP Different?

Bettina Balint Shermyn Xiumin Neo Francesca MagrinelliEoin MulroyAnna LatorreMaria StamelouHuw R Morris Amit Batla Kailash P Bhatia

Published in: Movement disorders clinical practice (2024)

We present a South Asian cohort of PSP patients with a higher than previously reported percentages of early-onset disease, family history and atypical clinical manifestations. These patients do not fit easily into the PSP phenotypes defined by the current MDS criteria. Dedicated clinicopathological and genetic tests are needed in this population to dissect the pathogenesis of clinically-defined PSP.

Keyphrases

early onset
end stage renal disease
late onset
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
copy number
dna methylation
drug induced