Neurofilament light is a biomarker of brain involvement in lupus and primary Sjögren's syndrome.

Anne B TjensvollMaria B LauvsnesHenrik ZetterbergJan T KvaløyIngeborg KvivikStian S MaroniOle J GreveMona K BeyerShunsei HirohataChaim PuttermanGuido AlvesErna HarboeKaj BlennowLasse G GøranssonRoald Omdal

Published in: Journal of neurology (2020)

Increased concentration of NfL in CSF is a marker of cerebral involvement in patients with SLE and pSS, is strongly associated with the presence of anti-NR2 antibodies, and correlates with cognitive impairment in several domains.

Keyphrases

disease activity
systemic lupus erythematosus
cognitive impairment
rheumatoid arthritis
cerebrospinal fluid
cerebral ischemia
subarachnoid hemorrhage
white matter
resting state
case report
brain injury
blood brain barrier