Causal association of cognitive reserve on Alzheimer's disease with putative sex difference.

Hao WangBrin Sara RosenthalCarolina MakowskiMin-Tzu LoOle A AndreassenRany M SalemLinda K McEvoyMark FiecasChi-Hua Chen

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2021)

Lower cognitive reserve is causally related to AD. The stronger causal link between cognitive performance and AD in females, despite similar PRS between sexes, suggest these differences may result from gene-environmental interactions accumulated over the lifespan.

Keyphrases

copy number
cognitive decline
gene expression
risk assessment
human health
mild cognitive impairment
genome wide identification
drug induced