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Hexokinase 2 is dispensable for T cell-dependent immunity.

Manan M MehtaSamuel E WeinbergElizabeth M SteinertKrishan ChhibaCarlos Alberto MartinezPeng GaoHarris R PerlmanPaul BryceNissim HayNavdeep S Chandel
Published in: Cancer & metabolism (2018)
HK2 is a highly upregulated enzyme in cancer and in T cells. The requirement for HK2 in various cancer models has been described previously. Our finding that T cells are able to withstand the loss of HK2 indicates that HK2 may be a promising candidate for cancer therapy. Furthermore, we identify several other potential metabolic targets in T-ALL leukemia that could spare T cell function.
Keyphrases
  • papillary thyroid
  • high glucose
  • cancer therapy
  • squamous cell
  • drug delivery
  • acute myeloid leukemia
  • endothelial cells
  • lymph node metastasis
  • risk assessment
  • childhood cancer
  • young adults