MicroRNA-744/transforming growth factor β1 relationship regulates liver cirrhosis.

Shuang RenJiamei ChenQinglan WangXuewei LiYing XuXiao ZhangYongping MuHua ZhangShuang HuangPing Liu

Published in: Hepatology international (2019)

MiR-744-led suppression in HSC activation is most likely through TGFβ1 because exogenous TGFβ1 nearly negated miR-744 Agomir's action. This study suggests that reduction of miR-744 is a reliable biomarker for LC and miR-744/TGFβ1 relationship is a key regulator of LC.

Keyphrases

transforming growth factor
cell proliferation
long non coding rna
epithelial mesenchymal transition
long noncoding rna
simultaneous determination
solid phase extraction