Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases.
Zahra MohtashamiMithalesh Kumar SinghFarid Thomaz NetoNasim SalimiaghdamHossein HasanpourM Cristina KenneyPublished in: Antioxidants (Basel, Switzerland) (2023)
Mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) is the most unearthed peptide encoded by mitochondrial DNA (mtDNA). It is an important regulator of the nuclear genome during times of stress because it promotes an adaptive stress response to maintain cellular homeostasis. Identifying MOTS-c specific binding partners may aid in deciphering the complex web of mitochondrial and nuclear-encoded signals. Mitochondrial damage and dysfunction have been linked to aging and the accelerated cell death associated with many types of retinal degenerations. Furthermore, research on MOTS-c ability to revive oxidatively stressed RPE cells has revealed a significant protective role for the molecule. Evidence suggests that senescent cells play a role in the development of age-related retinal disorders. This review examines the links between MOTS-c, mitochondria, and age-related diseases of the retina. Moreover, the untapped potential of MOTS-c as a treatment for glaucoma, diabetic retinopathy, and age-related macular degeneration is reviewed.
Keyphrases
- diabetic retinopathy
- oxidative stress
- mitochondrial dna
- induced apoptosis
- optical coherence tomography
- cell death
- cell cycle arrest
- copy number
- optic nerve
- age related macular degeneration
- minimally invasive
- endoplasmic reticulum stress
- transcription factor
- gene expression
- risk assessment
- cell proliferation
- climate change
- reactive oxygen species