The GC-content at the 5' ends of human protein-coding genes is undergoing mutational decay.
Yi QiuYoon Mo KangChristopher KorfmannFanny PouyetAndrew EckfordAlexander F PalazzoPublished in: Genome biology (2024)
Our results indicate that the dynamics of this GC-peak in amniotes is largely shaped by historic patterns of recombination. Since decay of GC-content towards the mutation rate equilibrium is the default state for non-functional DNA, the observed decrease in GC-content at TSSs in apes and rodents indicates that the GC-peak is not being maintained by selection on most protein-coding genes in those species.
Keyphrases
- gas chromatography
- genome wide
- endothelial cells
- dna damage
- mass spectrometry
- amino acid
- molecular dynamics
- functional connectivity
- single molecule
- bioinformatics analysis
- dna repair
- binding protein
- dna methylation
- small molecule
- tandem mass spectrometry
- induced pluripotent stem cells
- transcription factor
- genome wide analysis
- genetic diversity
- circulating tumor cells