Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia.

Manman DengJie ZhaZhiwu JiangXian JiaYuanfei ShiPeng LiXiao Lei ChenZhihong FangZhiqiang DuManman Deng

Published in: Journal of translational medicine (2018)

Our study indicates that Apatinib exerts its anti-leukemia effect by inducing apoptosis through suppressing the VEGFR2 signaling pathway, supporting a potential role for Apatinib in the treatment of ALL.

Keyphrases

signaling pathway
acute lymphoblastic leukemia
acute myeloid leukemia
bone marrow
oxidative stress
pi k akt
endoplasmic reticulum stress
allogeneic hematopoietic stem cell transplantation
cell cycle arrest
cell death
epithelial mesenchymal transition
induced apoptosis
cell therapy