Cytoplasmic ribosomes on mitochondria alter the local membrane environment for protein import.

Ya-Ting ChangBenjamin A Barad Hamidreza Rahmani Brian M Zid Danielle A Grotjahn

Published in: bioRxiv : the preprint server for biology (2024)

using cryo-electron tomography. They show that ribosomes cluster, make multiple contacts with, and induce local changes to the mitochondrial membrane ultrastructure at import sites.

Keyphrases

electron microscopy
oxidative stress
high resolution
cell death
protein protein
binding protein
reactive oxygen species
small molecule
amino acid
endoplasmic reticulum
mass spectrometry