Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits.
Christoffer NordIwan JonesMaria Garcia-MaestreAnna-Carin HägglundLeif CarlssonPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)
This study establishes a critical role for mTORC1-signaling during retinal lamination and demonstrates that this pathway regulates diverse developmental mechanisms involved in driving the stratified arrangement of neurons during CNS development.