Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer.

Dieuwertje AugustijnJoannes F M JacobsHenk Russcher

Published in: Clinical chemistry and laboratory medicine (2021)

The agreement for the free light chains is highest between the Freelite and the Diazyme assay and fair for the KLoneus assay. However, concordance of the FLC-ratio is highest when the Freelite and KLoneus assays were compared. Our data suggest that concordance for the Diazyme assay could be improved by recalibration. Because of absolute differences between the three methods in individual patients, none of the three FLC assays can be used interchangeably.

Keyphrases

high throughput
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
single cell
prognostic factors
peritoneal dialysis
electronic health record
patient reported
artificial intelligence