Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis.
Mohammad Shadab AliJay SinghMd Tanjim AlamAnita ChopraSudheer AravaAshu Seith BhallaSaurabh MittalAnant MohanDipendra K MitraVijay HaddaPublished in: Molecular biology reports (2022)
Pulmonary fibrosis is the key feature of majority of idiopathic interstitial pneumonias (IIPs) as well as many patients with post-COVID-19. The pathogenesis of pulmonary fibrosis is a complex molecular process that involves myriad of cells, proteins, genes, and regulatory elements. The non-coding RNA mainly miRNA, circRNA, and lncRNA are among the key regulators of many protein coding genes and pathways that are involved in pulmonary fibrosis. Identification and molecular mechanisms, by which these non-coding RNA molecules work, are crucial to understand the molecular basis of the disease. Additionally, elucidation of molecular mechanism could also help in deciphering a potential diagnostic/prognostic marker as well as therapeutic targets for IIPs and post-COVID-19 pulmonary fibrosis. In this review, we have provided the latest findings and discussed the role of these regulatory elements in the pathogenesis of pulmonary fibrosis associated with Idiopathic Interstitial Pneumonia and Covid-19.
Keyphrases
- pulmonary fibrosis
- coronavirus disease
- sars cov
- transcription factor
- respiratory syndrome coronavirus
- genome wide
- machine learning
- bioinformatics analysis
- gene expression
- nucleic acid
- risk assessment
- genome wide identification
- cell cycle arrest
- cell proliferation
- cell death
- long non coding rna
- amino acid
- intensive care unit
- protein protein
- respiratory failure
- pi k akt