Template-Free Synthesis of Porous Fluorescent Carbon Nanomaterials with Gluten for Intracellular Imaging and Drug Delivery.
Yalan XuChan WangTao WuGuoxia RanQijun SongPublished in: ACS applied materials & interfaces (2022)
A series of carbon nanomaterials, including carbon dots, carbon nanorings (CNRs), and porous carbon nanoballs, were facilely prepared by a template-free hydrothermal treatment of gluten as the sole carbon source. Driven by the hydrophobicity interaction, a concentration-dependent self-assembly of gluten was observed in an aqueous solution, leading to the subsequent formation of different morphologies of carbon nanomaterials in a hydrothermal treatment. Among these carbon nanomaterials, the CNRs exhibit bright photoluminescence with a quantum yield of 47.0%. Furthermore, CNRs also have a large surface area and low toxicity, making them an excellent drug carrier for chemotherapeutics. A model drug molecule doxorubicin (DOX) was successfully loaded on the CNRs, and the CNRs-DOX complexes exhibit a pH-dependent DOX release behavior. Compared with free DOX, the CNRs-DOX complexes can induce a higher level of apoptosis and lower level of necrosis, showing promise as anticancer agents.
Keyphrases
- drug delivery
- oxidative stress
- quantum dots
- cancer therapy
- celiac disease
- emergency department
- cell proliferation
- high resolution
- cell death
- endoplasmic reticulum stress
- risk assessment
- deep learning
- artificial intelligence
- adverse drug
- fluorescence imaging
- tandem mass spectrometry
- photodynamic therapy
- highly efficient